Every organ and even every cell in our body has circadian or 24 h clock. Circadian clocks turn on and off thousands of genes at the right time of the day or night. These rhythms work together to maintain healthy balance of brain chemicals, hormones, and nutrients. When our rhythms break down we are more likely to suffer from a wide range of diseases from depression to cancer. We can tune our daily habits of eating, sleeping or getting the right amount of light to sustain our circadian rhythms. Healthy rhythms nurture healthy body and healthy mind. Dr. Satchidananda Panda, a professor at the Salk Institute for Biological Studies in La Jolla, California. Satchin’s work deals specifically with the timing of food and it’s relationship with our biological clocks governed by circadian rhythm and also the circadian rhythm in general.

Professor Panda explores the genes, molecules and cells that keep the whole body on the same circadian clock. A section of the hypothalamus called the suprachiasmatic nucleus (SCN) lies at the center of the body’s master clock and gets input directly from light sensors in the eyes, keeping the rest of the body on schedule. Panda discovered how these light sensors work, as well as how cellular timekeepers in other parts of the body function. He also uncovered a novel blue light sensor in the retina that measures ambient light level and sets the time to go to sleep and wake up every day.

In the process of exploring how the liver’s daily cycles work, Panda found that mice which eat within a set amount of time (12 hours) resulted in slimmer, healthier mice than those who ate the same number of calories in a larger window of time, showing that when one eats may be as important as what one eats. If the benefits of this “12-hour diet” hold true in humans, it could have profound impacts on treating overeating disorders, diabetes and obesity.

The circadian clock, he found, even mediates the immune system. Mice with a crucial circadian molecule missing had higher levels of inflammation in their bodies than other mice, suggesting that genes and molecules involved in the circadian clock could be drug targets for conditions linked to inflammation, such as infections or cancer. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx

Narda Pitkethly created a system that profoundly simplifies learning how to read. Watch how her system reduces illiteracy and many of its negative consequences. Narda Pitkethly moved to Japan after college and discovered the Japanese had created a simple method of learning to read, called Hiragana. Through their method, Narda learned to read Japanese in a week. Within three months, her comprehension allowed her to communicate freely in her home city of Fukuoka.
In 1988 Narda moved from Japan to Sun Valley because the small community and year-round outdoor activities enticed her. An accomplished glassblower, she often travels to Boise to create works of art.
When her daughter was identified as a challenged reader in the first grade, Narda discovered that English is one of the hardest languages in the world to learn to read, even for native speakers. Narda analyzed the English alphabet to understand why it is so difficult (1 in 4 children grow up without learning to read). She organized the letters in the same way the Japanese organized their Hiragana characters. Narda reveals an approach to the English language you have never seen before. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx

Many people are doing jobs in fear; fear that they might not make the best out of their lives. Priya Parker provides seven techniques to help you quit your life and reboot.
She invites you to use these techniques to explore the biggest needs in the world that you might have the passion and the capacity to address.

Priya is an advisor to leaders and organizations on strategy, vision and purpose. Her company, Thrive Labs, works with individuals and teams to help them identify what they care about most and align it with market realities. Her research includes identifying what are the driving factors that lead people to thriving and what blocks them from it. She helps organizations keep and grow their culture and values as they scale. Drawing on 10 years of conflict resolution facilitation in the United States, India and the Middle East, Priya designs visioning and innovation labs that help organizations grow from the root.

She has run her signature Labs for leading global firms as well as startups from a variety of disciplines. Her clients include disruptors from the fields of fashion, technology, design, development, film, comedy and government. Priya is an expert in innovative facilitation and process design and incorporates creative visioning and movement techniques into her work. Her goal is to help people spend more of their time building things that make them and others come alive.

Priya received her B.A. in Political and Social Thought at the University of Virginia, Phi Beta Kappa, and an M.B.A. from MIT Sloan and an M.P.A. from the Harvard Kennedy School, where she received the Public Service Fellowship.

According to Barbara Sher we have to change our common understanding of why we so often fail to bring our dreams into reality – blaming bad attitude, negative thinking or lack of effort. Heartfelt, funny and surprising stories told by a lady whos been helping other peoples dreams for many decades.

— Podle Barbary Sher musíme přehodnotit běžný názor, že za neuskutečněné sny může špatný přístup, negativní myšlení nebo nedostatek píle. Překvapující, vtipné a srdečné vyprávění dámy, která již několik desetiletí pomáhá lidem na cestě k realizaci jejich snů.

— Barbaře přezdívají „kmotra životního koučování“. Je autorkou šesti bestsellerů, vede semináře po celém světě, školí v největších firmách a přednáší na univerzitách. Ve svých knihách a lekcích propojuje velké množství praktických zkušeností s osobitým humorem. Pokud jste někdy bojovali s neschopností vybrat si jen jeden cíl a na něj se zaměřit nebo máte pocit, že pro uskutečnění svých snů nemáte dost pevnou vůli, pak Vás Barbara snadno utěší. Stejně jako ty, kteří se bojí, že některé věci už v životě prošvihli.

Barbara má veliký rozhled po světě (žila mimo jiné v Turecku, Francii i Německu) a asi nejhezčí na jejích lekcích je, že se co chvíli neubráníte smíchu nad tím, jak jsou některé věci prosté.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx

This talk was given at a local TEDx event, produced independently of the TED Conferences. In this talk Andrew Tarvin talks about how he brought humor to the workplace while he worked at Procter

This talk was given at a local TEDx event, produced independently of the TED Conferences. Jennifer discovered the ten-item wardrobe concept while living in Paris with Madame Chic and her family. In this talk she shares her endearing story, tips on how you can make a ten-item wardrobe work for you, and why living with fewer clothes can not only improve your style, but change your life.

Jennifer L. Scott is the internationally bestselling author of Lessons from Madame Chic and At Home with Madame Chic (Simon

This talk was given at a local TEDx event, produced independently of the TED Conferences. Dr. Crum says the biggest game changer is “YOU, by harnessing the power of your mind." She explores scientific results that show the influence of the mindset on the body, and how changing the subjective mindset produced different outcomes. Dr. Crums work is inspired in part by the placebo effect, and has implications that stretch far beyond the realm of medicine.

Dr. Crum is a professor, psychologist, and researcher investigating how mindsets affect health and behavior.

Dr. Crums research focuses on how changes in subjective mindsets—the lenses through which information is perceived, organized, and interpreted—can alter objective reality through behavioral, psychological, and physiological mechanisms. Her work is, in part, inspired by research on the placebo effect, a notable and consistent demonstration of the ability of the mindset to elicit healing properties in the body. She is interested in understanding how mindsets affect important outcomes outside the realm of medicine, in the domains of behavioral health and organizational behavior.

About TEDx, x = independently organized event In the spirit of ideas worth spreading, TEDx is a program of local, self-organized events that bring people together to share a TED-like experience. At a TEDx event, TEDTalks video and live speakers combine to spark deep discussion and connection in a small group. These local, self-organized events are branded TEDx, where x = independently organized TED event. The TED Conference provides general guidance for the TEDx program, but individual TEDx events are self-organized.* (*Subject to certain rules and regulations)

Graphene – the material that you find at the end of your pencil – has been hailed as a wonder material of the 21st century. Researchers from the Centre for Graphene Science at the University of Exeter explain how it is capable of revolutionising the way our technology works, making it stronger, better and faster. Monica Craciun is Professor in the Engineering Department at the University of Exeter and a leading expert in nanomaterials. She has been awarded a prestigious Engineering Fellowship for Growth, aimed at maintaining UK’s leadership in Advanced Materials (which is one of the eight Great Technologies identified as crucial for the future prosperity of the UK).

Dimitar, who is currently a Research Consultant at Cast, was Monica’s PhD student at the University of Exeter. He came up with the idea of using graphene to make concrete stronger, which ultimately leads to 50% reduction of carbon emissions in the construction industry. His invention attracted a lot of media attention and got shortlisted for the UK TechFest 2018 awards. This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at www.ted.com/tedx

Дебби Стерлинг — инженер и основательница GoldieBlox, компании по производству игрушек, возникшей для воспитания нового поколения женщин-инженеров. Она нашла своё жизненное призвание в сокращении пропасти между мужчинами и женщинами в науках, технологиях, проектировании и математике. В этом выступлении TEDx Дебби делиться историей о том, как у неё возникла страсть к инженерному делу, а также новаторская идея создания GoldieBlox — инженерных игрушек для девочек.

Это выступление записано на мероприятии TEDxPSU, организованном независимо от TED Conferences.

Modern medicine can treat severe injuries like never before, but even with todays technology, there are limits to the healing of tissue in wounded adults. In an optimistic glimpse into the future, Dr. George Christ introduces the growing concept of regenerative medicine, and its role in the healing of veterans and civilians.

Dr. George Christ is a Professor of Biomedical Engineering and Orthopaedic Surgery at the University of Virginia. He is also the Director of Basic and Translational Research in the Department of Orthopaedic Surgery at the UVA Medical School. He is also a co-inventor of more than 26 patents related to gene therapy for the treatment of human smooth muscle disorders and tissue engineering technologies.

This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at ted.com/tedx